The Mount Sinai Bone Program, Department of Medicine, Mount Sinai School of Medicine, New York, New York, USA.
Ann N Y Acad Sci. 2010 Nov;1211:107-12. doi: 10.1111/j.1749-6632.2010.05812.x.
Bisphosphonates form a class of drugs commonly used to treat disorders of osteoclastic bone resorption, including osteoporosis, Paget's disease of the bone, rheumatoid arthritis, and bone metastases. Although long established as the therapy of choice to treat such disorders, bisphosphonates' potential in treating cancer is garnering interest. Bisphosphonates have been demonstrated to inhibit tumor growth and metastasis, induce apoptosis in tumor cells, and encourage immune reactions against tumor cells. Current applications of bisphosphonates in cancer treatment include their use to treat skeletal metastases and as an adjuvant to endocrine therapy. This review explores bisphosphonates' current clinical utility and potential as a crossover cancer therapy.
双膦酸盐是一类常用于治疗破骨细胞性骨吸收紊乱的药物，包括骨质疏松症、骨关节炎、类风湿关节炎和骨转移。尽管双膦酸盐作为治疗这些疾病的首选疗法已经确立了很长时间，但它们在癌症治疗中的潜力正在引起关注。双膦酸盐已被证明可以抑制肿瘤生长和转移，诱导肿瘤细胞凋亡，并促进针对肿瘤细胞的免疫反应。目前双膦酸盐在癌症治疗中的应用包括用于治疗骨骼转移和作为内分泌治疗的辅助治疗。本综述探讨了双膦酸盐目前的临床应用价值及其作为交叉癌症治疗的潜力。
