L-CHOP 方案与 L-CHOP 方案联合 CCNU 和 MOPP 穿插治疗（L-CHOP-CCNU-MOPP）治疗犬淋巴瘤的比较。

Comparison between L-CHOP and an L-CHOP protocol with interposed treatments of CCNU and MOPP (L-CHOP-CCNU-MOPP) for lymphoma in dogs.

机构信息

Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA.

出版信息

Vet Comp Oncol. 2010 Dec;8(4):243-53. doi: 10.1111/j.1476-5829.2010.00224.x.

DOI:10.1111/j.1476-5829.2010.00224.x

Abstract

An L-CHOP protocol with interposed treatments of CCNU and MOPP (L-CHOP-CCNU-MOPP) was evaluated in 66 dogs with stages III-V lymphoma. Results were compared with a historical group of 71 dogs treated with an L-CHOP protocol. Complete remission (CR) rates (85 and 80%, respectively) did not differ significantly between protocols (P = 0.48). First CR duration for dogs treated with L-CHOP-CCNU-MOPP was significantly longer: median, 317 days; 2-year CR rate, 35% versus median, 298 days; 2-year CR rate, 13%, P = 0.05). For the L-CHOP-CCNU-MOPP protocol, dogs in substage-b had a 4.3 times greater hazard of having a relapse than dogs in substage-a (P = 0.002). Frequency of adverse chemotherapy-associated gastrointestinal effects did not differ between protocols (P = 0.77). Neutropenia (primarily after CCNU) occurred more frequently in dogs treated with L-CHOP-CCNU-MOPP (P < 0.001). In summary, the L-CHOP-CCNU-MOPP protocol showed an improved duration of first CR as compared with an L-CHOP protocol, but the relevance of this finding might be subject to clinical judgement.

摘要

一项 L-CHOP 方案联合 CCNU 和 MOPP （L-CHOP-CCNU-MOPP）方案治疗 III-V 期淋巴瘤的 66 例犬的研究结果与 71 例接受 L-CHOP 方案治疗的历史对照组进行了比较。结果显示，两种方案的完全缓解率（分别为 85%和 80%）无显著差异（P = 0.48）。接受 L-CHOP-CCNU-MOPP 方案治疗的犬首次完全缓解的持续时间明显更长：中位数为 317 天；2 年完全缓解率为 35%，而接受 L-CHOP 方案治疗的犬的中位数为 298 天；2 年完全缓解率为 13%，P = 0.05）。对于 L-CHOP-CCNU-MOPP 方案，亚组-b 的犬比亚组-a 的犬复发的风险高 4.3 倍（P = 0.002）。两种方案的化疗相关胃肠道不良事件的频率无显著差异（P = 0.77）。中性粒细胞减少（主要发生在 CCNU 后）在接受 L-CHOP-CCNU-MOPP 治疗的犬中更为常见（P < 0.001）。总之，与 L-CHOP 方案相比，L-CHOP-CCNU-MOPP 方案显示出首次完全缓解的持续时间有所改善，但这一发现的相关性可能需要临床判断。