胎儿铅暴露的关键期：对妊娠期长度的不良影响和早产风险。
Critical windows of fetal lead exposure: adverse impacts on length of gestation and risk of premature delivery.
机构信息
Department of Environmental Health Sciences, University of Michigan School of Public Health, 109 S. Observatory Street, Ann Arbor, MI 48109, USA.
出版信息
J Occup Environ Med. 2010 Nov;52(11):1106-11. doi: 10.1097/JOM.0b013e3181f86fee.
OBJECTIVE
Research on the role of environmental lead exposure in the complex etiology of premature birth has yielded inconsistent results. We assessed the trimester-specific effect of prenatal lead exposure on gestational age and risk of premature delivery.
METHODS
We used linear and logistic regression to identify critical windows of susceptibility to lead exposure on gestational length.
RESULTS
In single-trimester models, decreases in gestational length were most strongly associated with first and second trimester blood lead. In adjusted logistic regression models, a one-standard deviation increase in second trimester blood lead was associated with an odds ratio of prematurity of 1.75 (95% CI: 1.02, 3.02).
CONCLUSIONS
Maternal whole blood lead levels measured during first and second trimesters yielded the most prominent inverse association with length of gestation and increased the risk of prematurity.
目的
关于环境铅暴露在早产复杂病因学中的作用的研究结果并不一致。我们评估了产前铅暴露对胎龄和早产风险的特定孕期影响。
方法
我们使用线性和逻辑回归来确定铅暴露对妊娠长度的易感性的关键窗口期。
结果
在单孕期模型中，妊娠长度的减少与第一和第二孕期的血铅水平下降最为密切相关。在调整后的逻辑回归模型中，第二孕期血铅水平增加一个标准差与早产的比值比为 1.75（95%CI：1.02，3.02）。
结论
在第一和第二孕期测量的母体全血铅水平与妊娠长度呈最显著的负相关，并增加了早产的风险。
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