Dar Javeed, Mughal Inam, Hassan Hilali, Al Mekki Taj E, Chapunduka Zivani, Hassan Imad S A
Armed Forces Hospital, Southern Region, Khamis Mushayt, Kingdom of Saudi Arabia.
Ger Med Sci. 2010 Oct 8;8:Doc25. doi: 10.3205/000114.
Quantitation of D-dimer level during a sickling crisis and its correlation with other clinical abnormalities.
Prospective longitudinal study.
Armed Forces Hospital, Southern Region, Kingdom of Saudi Arabia.
Adult patients (12 years and older) admitted acutely with a sickle cell crisis who consent to taking part in the study. Candidates may re-participate if they are readmitted with a further acute painful crisis.
36 patients with homozygous sickle cell disease consented to take part in the study. D-dimer levels were raised in 31 (68.9%) of 45 episodes of painful crisis of whom 13 had an abnormal chest X-ray. Of those with a normal chest X-ray only one patient had a raised D-dimer level: sensitivity of 92.3%, specificity 40.6%, positive predictive value 38.7% and negative predictive value of 92.9% for an abnormal chest X-ray.
D-dimer levels are frequently raised during an acute painful crisis. A normal level has a high negative predictive value for an abnormal chest X-ray.
定量检测镰状细胞危象期间的D - 二聚体水平及其与其他临床异常情况的相关性。
前瞻性纵向研究。
沙特阿拉伯王国南部地区武装部队医院。
因镰状细胞危象急性入院且同意参与本研究的成年患者（12岁及以上）。若再次因急性疼痛性危象入院，符合条件者可再次参与。
36例纯合子镰状细胞病患者同意参与本研究。在45次疼痛性危象发作中，31次（68.9%）的D - 二聚体水平升高，其中13例胸部X线检查异常。胸部X线检查正常的患者中，仅1例D - 二聚体水平升高：胸部X线检查异常时，敏感性为92.3%，特异性为40.6%，阳性预测值为38.7%，阴性预测值为92.9%。
急性疼痛性危象期间D - 二聚体水平常升高。正常水平对胸部X线检查异常具有较高的阴性预测价值。
