J Cell Commun Signal. 2010 Oct;4(3):155-6. doi: 10.1007/s12079-010-0092-0. Epub 2010 Jun 17.
There is no treatment for fibrotic disease is a significant cause of mortality. CCN2 Members of the CCN family of matricellular proteins have a characteristic four domain structure. CCN2 (connective tissue growth factor) is believed to play an essential role in fibrogenesis. In a recent paper, data are provided that CCN5 (wisp2), which lacks the carboxy-terminal heparin-binding domain shared by the other CCN proteins, may act as a dominant-negative protein to suppress CCN2-mediated fibrogenesis. These data are consistent with the notion that different CCN proteins may enhance or suppress each other's action and also suggest that CCN5, may be used as a novel anti-fibrotic therapy.
目前尚无治疗纤维化疾病的方法，这是导致死亡率的一个重要原因。CCN 家族细胞基质蛋白中的成员具有典型的四结构域结构。CCN2（结缔组织生长因子）被认为在纤维化发生中发挥重要作用。在最近的一篇论文中提供的数据表明，缺乏其他 CCN 蛋白所共有的羧基末端肝素结合结构域的 CCN5（wisp2）可能作为一种显性负性蛋白来抑制 CCN2 介导的纤维化发生。这些数据与不同的 CCN 蛋白可能增强或抑制彼此作用的观点一致，并且还表明 CCN5 可作为一种新型抗纤维化治疗方法。
