Berland Todd, Oldenburg W Andrew
Curr Treat Options Gastroenterol. 2008 Feb;11(1):3-10. doi: 10.1007/s11938-008-0001-2.
Acute mesenteric ischemia is caused by a critical reduction in intestinal blood flow that frequently results in bowel necrosis and is associated with a high mortality. Clinicians must maintain a high index of suspicion because a prompt diagnosis and early aggressive treatment before the onset of bowel infarction results in reduced mortality. Medical management includes aggressive rehydration and the use of antibiotics, anticoagulation, vasodilators, and inhibitors of reperfusion injury. If acute mesenteric ischemia is suspected, early angiography is imperative, as it permits accurate diagnosis and possible therapeutic intervention. Therapeutic options during angiography depend on the cause of ischemia and include administering intra-arterial vasodilators and/or thrombolytic agents and angioplasty with or without stent placement. If interventional techniques are not possible or if the patient presents with suspicion of bowel infarction, surgery is warranted. Surgical techniques include superior mesenteric artery embolectomy or visceral artery bypass, which should be used before bowel resection to ensure only resection of nonviable bowel.
急性肠系膜缺血是由肠道血流严重减少引起的,常导致肠坏死,并伴有高死亡率。临床医生必须保持高度的怀疑指数,因为在肠梗死发作前迅速诊断并早期积极治疗可降低死亡率。药物治疗包括积极补液以及使用抗生素、抗凝剂、血管扩张剂和再灌注损伤抑制剂。如果怀疑急性肠系膜缺血,早期血管造影至关重要,因为它能实现准确诊断并可能进行治疗干预。血管造影期间的治疗选择取决于缺血原因,包括动脉内注射血管扩张剂和/或溶栓剂以及进行有或无支架置入的血管成形术。如果无法进行介入技术,或者患者疑似肠梗死,则需要进行手术。手术技术包括肠系膜上动脉栓子切除术或内脏动脉搭桥术,应在肠切除术前使用,以确保仅切除无活力的肠段。