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[急性肠系膜缺血的诊断与管理]

[Diagnosis and management of acute mesenteric ischemia].

作者信息

Dewitte A, Biais M, Coquin J, Fleureau C, Cassinotto C, Ouattara A, Janvier G

机构信息

Service d'anesthésie-réanimation II, CHU de Bordeaux, Maison du Haut-Lévêque, groupe hospitalier Sud, université Bordeaux-Segalen, avenue de Magellan, Pessac cedex, France.

出版信息

Ann Fr Anesth Reanim. 2011 May;30(5):410-20. doi: 10.1016/j.annfar.2011.02.013. Epub 2011 Apr 9.

Abstract

The prevalence of significant splanchnic arterial stenoses is increasing, but remains mostly asymptomatic due to abundant collateral circulation. Acute insufficiency of mesenteric arterial blood flow accounts for 60 to 70% of cases of mesenteric ischemia and results mostly from a superior mesenteric embolus. Despite major advances have been achieved in understanding the pathogenic mechanisms of bowel ischemia, its prognosis remains dismal with mortality rates about 60%. The diagnosis of acute mesenteric ischemia depends upon a high clinical suspicion, especially in patients with known risk factors. Rapid diagnosis is essential to prevent intestinal infarction. However, early signs and symptoms of mesenteric ischemia are non specific, and definitive diagnosis often requires radiologic examinations. Early and liberal implementation of angiography has been the major advance over the past 30 years which allowed increasing diagnostic accuracy of acute mesenteric ischemia. CT and MR-based angiographic techniques have emerged as alternatives less invasive and more accurate to analyse splanchnic vessels and evaluate bowel infarction. The goal of treatment of patients with acute mesenteric ischemia is to restore intestinal oxygenation as quickly as possible after initial management that includes rapid hemodynamic monitoring and support. Surgery should not be delayed in patients suspected of having intestinal necrosis.

摘要

重要内脏动脉狭窄的患病率正在上升,但由于丰富的侧支循环,大多数仍无症状。肠系膜动脉血流急性不足占肠系膜缺血病例的60%至70%,主要由肠系膜上动脉栓子引起。尽管在理解肠道缺血的发病机制方面取得了重大进展,但其预后仍然不佳,死亡率约为60%。急性肠系膜缺血的诊断依赖于高度的临床怀疑,尤其是在有已知危险因素的患者中。快速诊断对于预防肠梗死至关重要。然而,肠系膜缺血的早期体征和症状不具有特异性,明确诊断通常需要影像学检查。在过去30年中,早期和广泛实施血管造影是一项主要进展,它提高了急性肠系膜缺血的诊断准确性。基于CT和MR的血管造影技术已成为分析内脏血管和评估肠梗死的侵入性较小且更准确的替代方法。急性肠系膜缺血患者的治疗目标是在包括快速血流动力学监测和支持在内的初始处理后尽快恢复肠道氧合。对于怀疑有肠坏死的患者,不应延迟手术。

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