Menashe Y, Lunenfeld B, Pariente C, Frenkel Y, Mashiach S
Institute of Endocrinology, Chaim Sheba Medical Center, Tel Hashomer, Israel.
Fertil Steril. 1990 Mar;53(3):432-5. doi: 10.1016/s0015-0282(16)53336-6.
Recent observations claimed that growth hormone (GH) administration increased the sensitivity of the ovary to gonadotropin stimulation. These findings prompted us to assess whether ovarian response to human menopausal gonadotropin (hMG) is correlated to GH reserve. Before hMG administration, 25 patients were tested for GH reserve by administration of clonidine. Of the 25 patients, 8 showed a significant increase in GH (9.2 +/- 4.5 ng/mL) and needed a significantly lower dose of hMG/human chorionic gonadotropin to elicit a good ovarian response than the 17 patients who did not respond to clonidine administration may help to estimate the initial dose range of hMG necessary for induction of ovulation.
最近的观察结果表明，使用生长激素（GH）可提高卵巢对促性腺激素刺激的敏感性。这些发现促使我们评估卵巢对人绝经期促性腺激素（hMG）的反应是否与GH储备相关。在给予hMG之前，通过给予可乐定对25例患者进行了GH储备测试。在这25例患者中，8例GH显著升高（9.2±4.5 ng/mL），与17例对可乐定给药无反应的患者相比，这些患者诱导良好卵巢反应所需的hMG/人绒毛膜促性腺激素剂量显著更低。这可能有助于估计诱导排卵所需的hMG初始剂量范围。
