Blumenfeld Z, Dirnfeld M, Gonen Y, Abramovici H
Department of Obstetrics and Gynaecology, Rambam Medical Centre, Haifa, Israel.
Hum Reprod. 1994 Feb;9(2):209-13. doi: 10.1093/oxfordjournals.humrep.a138483.
To investigate the effect of co-treatment with growth hormone (GH) for ovulation induction with human menopausal gonadotrophins (HMG) on conception, we compared the pregnancy rate and response to co-treatment with GH versus HMG/human chorionic gonadotrophin (HCG) alone in a prospective, randomized, cross-over protocol of ovulation induction for either in-vivo or in-vitro fertilization (IVF). The main outcome measures were the amount of gonadotrophin used and conception. Co-treatment with GH was associated with a reduction of approximately 30% in gonadotrophin requirement. In 24 clonidine negative patients 14 pregnancies were achieved (58.3%) either in the GH/HMG/HCG cycle or in the succeeding one. GH co-treatment did not generate any pregnancy in eight clonidine positive patients. We conclude that growth hormone may increase the pregnancy rate when combined with HMG/HCG for ovulation induction, not only in the co-treatment cycle but also in the succeeding one. The beneficial, synergistic effect of GH co-treatment was detected in clonidine negative but not in clonidine positive infertile patients.
为研究生长激素（GH）与人绝经期促性腺激素（HMG）联合用于诱导排卵对受孕的影响，我们采用前瞻性、随机、交叉方案，对体内或体外受精（IVF）诱导排卵时GH联合治疗与单独使用HMG/人绒毛膜促性腺激素（HCG）的妊娠率及反应进行了比较。主要观察指标为促性腺激素用量和受孕情况。GH联合治疗使促性腺激素需求量减少了约30%。在24例可乐定阴性患者中，在GH/HMG/HCG周期或随后的周期中有14例成功妊娠（58.3%）。8例可乐定阳性患者在GH联合治疗中未出现妊娠。我们得出结论，生长激素与HMG/HCG联合用于诱导排卵时，不仅在联合治疗周期，而且在随后的周期中，都可能提高妊娠率。在可乐定阴性而非可乐定阳性的不孕患者中检测到了GH联合治疗的有益协同作用。
