Neoplasma. 2011;58(1):58-64. doi: 10.4149/neo_2011_01_58.
The aim of this study was to analyze the relationship of serum leptin as well as adiponectin and the manifestation of pancreatic cancer (PC). Serum leptin, adiponectin, glucose homeostasis and insulin resistance (expressed as HOMA-IR) were investigated in 64 patients with newly diagnosed PC and compared with 64 healthy controls (CON group) and 75 patients with type 2 diabetes (DM2). Seventy percent of newly diagnosed PC patients had DM2. The levels of leptin were lower, whilst adiponectin/leptin ratio was higher in PC patients (both with and without DM2), in comparison with CON and DM2 groups (P < 0.001) independently of age, BMI and waist circumference. Newly diagnosed PC is characterized with lower leptin concentrations and higher adiponectin/leptin ratio in comparison with CON or DM2 individuals. Analysis of these parameters could help in the screening of persons in high risk for PC, especially in those with DM2.
adiponectin, leptin, pancreatic cancer, type 2 diabetes mellitus.
本研究旨在分析血清瘦素和脂联素与胰腺癌（PC）表现之间的关系。在 64 名新诊断为 PC 的患者中检测了血清瘦素、脂联素、葡萄糖稳态和胰岛素抵抗（以 HOMA-IR 表示），并与 64 名健康对照者（CON 组）和 75 名 2 型糖尿病（DM2）患者进行了比较。新诊断的 PC 患者中有 70%患有 DM2。与 CON 和 DM2 组相比（P < 0.001），无论年龄、BMI 和腰围如何，PC 患者（无论是否患有 DM2）的瘦素水平较低，而脂联素/瘦素比值较高。与 CON 或 DM2 个体相比，新诊断的 PC 患者的瘦素浓度较低，脂联素/瘦素比值较高。分析这些参数有助于筛选 PC 高危人群，尤其是 DM2 患者。
脂联素、瘦素、胰腺癌、2 型糖尿病。
