Zemanová Milada, Staňková Barbora, Ušiakova Zuzana, Tvrzická Eva, Pazdro Alexandr, Petruželka Luboš, Zeman Miroslav
Clinic of Oncology, 1st Faculty of Medicine of Charles University in Prague and General University Hospital, Prague, Czech Republic.
4th Department of Internal Medicine, 1st Faculty of Medicine of Charles University in Prague and General University Hospital, Prague, Czech Republic.
Med Sci Monit. 2014 Nov 19;20:2351-7. doi: 10.12659/MSM.891088.
The convergence of nutritional, genetic, and inflammatory factors plays a significant role in the pathophysiology of squamous cell esophageal cancer (SCEC). The parameters of inflammation, indices of nutritional status, and adipocyte-derived hormones such as leptin, adiponectin, and resistin have been shown to be prognostic factors in some gastrointestinal and pancreatic cancers.
MATERIAL/METHODS: Forty-two patients with SCEC were subjected to a multimodal regimen of concurrent neoadjuvant chemoradiotherapy (CRT) followed by surgery. We retrospectively analyzed the impact of pretreatment values of serum leptin, adiponectin, resistin, soluble leptin receptor, C-reactive protein, TNF alpha, leukocytes, and indices of nutritional status (BMI, plasma total protein, albumin, cholesterol, and triacylglycerols) on overall survival (OS).
Univariate analysis revealed significant a negative correlation between OS and serum adiponectin (p=0.027), and a positive relationship was found between serum albumin (p=0.002), cholesterol (p=0.049) level, and OS. In multivariate analysis, only the trend (p=0.086) for negative serum adiponectin association with the OS was observed.
In men with SCEC treated by neoadjuvant concurrent CRT and esophagectomy, high pretreatment level of serum adiponectin was associated with shorter OS while the serum albumin and cholesterol were associated with longer OS.
营养、遗传和炎症因素的相互作用在食管鳞状细胞癌（SCEC）的病理生理学中起着重要作用。炎症参数、营养状况指标以及瘦素、脂联素和抵抗素等脂肪细胞衍生激素已被证明是某些胃肠道和胰腺癌的预后因素。
材料/方法：42例SCEC患者接受了新辅助同步放化疗（CRT）联合手术的多模式治疗方案。我们回顾性分析了血清瘦素、脂联素、抵抗素、可溶性瘦素受体、C反应蛋白、肿瘤坏死因子α、白细胞的预处理值以及营养状况指标（BMI、血浆总蛋白、白蛋白、胆固醇和三酰甘油）对总生存期（OS）的影响。
单因素分析显示OS与血清脂联素之间存在显著负相关（p=0.027），血清白蛋白（p=0.002）、胆固醇（p=0.049）水平与OS之间存在正相关。多因素分析中，仅观察到血清脂联素与OS负相关的趋势（p=0.086）。
在接受新辅助同步CRT和食管切除术治疗的SCEC男性患者中，血清脂联素预处理水平高与OS较短相关，而血清白蛋白和胆固醇与OS较长相关。
