Registre des Cancers du Sein et autres Cancers Gynécologiques de Côte d'Or, Centre Georges François Leclerc, Dijon, France.
BMC Cancer. 2010 Nov 10;10:622. doi: 10.1186/1471-2407-10-622.
The aim of this population-based study was to assess independent prognostic factors in ovarian cancer using relative survival (RS) and to investigate changes in RS rates from 1982 to 2005.
Data on 748 patients with ovarian cancer were provided by the Côte d'Or gynaecologic cancer registry. The RS was estimated using a generalized linear model with a Poisson error structure. Relative survival and its 95% confidence interval (CI) were described at the following specific time points 1, 3 and 5 years. The effect of prognostic factors on survival was assessed with multivariate analyses of RS.
The median follow-up was 12 years. The RS rates at 1, 3 and 5 years were 81%, 55% and 44%, respectively. As compared with the period 1982-1989, an improvement in survival was found for the period 1998-2005: HR = 0.52[0.40-0.67]. Women who lived in urban areas had better RS: HR = 0.82[0.67-0.99]. Patients with epithelial types of ovarian cancer other than mucinous or endometrioid cancer had worse RS than those with serous histology. Age ≥ 70 years was associated with lower survival.
Period of diagnosis, stage at diagnosis, histology, place of residence and age were independent prognostic factors for survival in ovarian cancer. An improvement in the survival rate was observed after 1998 but a significant improvement was limited to advanced stage cancers.
本基于人群的研究旨在使用相对生存率（RS）评估卵巢癌的独立预后因素，并探讨 1982 年至 2005 年 RS 率的变化。
科多尔妇科癌症登记处提供了 748 例卵巢癌患者的数据。使用具有泊松误差结构的广义线性模型估计相对生存率。描述了以下特定时间点 1、3 和 5 年的相对生存率及其 95%置信区间（CI）。使用 RS 的多变量分析评估预后因素对生存的影响。
中位随访时间为 12 年。RS 率在 1、3 和 5 年分别为 81%、55%和 44%。与 1982-1989 年相比，1998-2005 年的生存率有所提高：HR=0.52[0.40-0.67]。居住在城市地区的女性 RS 更好：HR=0.82[0.67-0.99]。与浆液组织学相比，卵巢癌上皮类型为黏液性或子宫内膜样癌以外的患者 RS 较差。年龄≥70 岁与生存率降低相关。
诊断期、诊断时的分期、组织学、居住地和年龄是卵巢癌生存的独立预后因素。1998 年后生存率有所提高，但仅在晚期癌症中显著提高。
