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本文引用的文献

1
The apical-basal cell polarity determinant Crumbs regulates Hippo signaling in Drosophila.顶端-基底细胞极性决定因子 Crumbs 调控果蝇中的 Hippo 信号通路。
Proc Natl Acad Sci U S A. 2010 Sep 7;107(36):15810-5. doi: 10.1073/pnas.1004060107. Epub 2010 Aug 23.
2
Warts and Yorkie mediate intestinal regeneration by influencing stem cell proliferation.疣和约克夏犬通过影响干细胞增殖来介导肠道再生。
Curr Biol. 2010 Sep 14;20(17):1580-7. doi: 10.1016/j.cub.2010.07.041. Epub 2010 Aug 19.
3
Upstream regulation of the hippo size control pathway.调控 hippo 大小控制通路的上游因子。
Curr Biol. 2010 Jul 13;20(13):R574-82. doi: 10.1016/j.cub.2010.05.023.
4
The apical transmembrane protein Crumbs functions as a tumor suppressor that regulates Hippo signaling by binding to Expanded.顶端跨膜蛋白 Crumbs 通过与 Expanded 结合来调节 Hippo 信号，作为一种肿瘤抑制因子发挥作用。
Proc Natl Acad Sci U S A. 2010 Jun 8;107(23):10532-7. doi: 10.1073/pnas.1004279107. Epub 2010 May 24.
5
Lgl, aPKC, and Crumbs regulate the Salvador/Warts/Hippo pathway through two distinct mechanisms.Lgl、aPKC 和 Crumbs 通过两种不同的机制调节 Salvador/Warts/Hippo 通路。
Curr Biol. 2010 Apr 13;20(7):573-81. doi: 10.1016/j.cub.2010.01.055. Epub 2010 Apr 1.
6
Crumbs regulates Salvador/Warts/Hippo signaling in Drosophila via the FERM-domain protein Expanded.crumbs 通过 FERM 结构域蛋白 expanded 调控果蝇中的 Salvador/Warts/Hippo 信号通路。
Curr Biol. 2010 Apr 13;20(7):582-90. doi: 10.1016/j.cub.2010.03.019. Epub 2010 Apr 1.
7
Ajuba LIM proteins are negative regulators of the Hippo signaling pathway.Ajuba LIM 蛋白是 Hippo 信号通路的负调控因子。
Curr Biol. 2010 Apr 13;20(7):657-62. doi: 10.1016/j.cub.2010.02.035. Epub 2010 Mar 18.
8
The WW domain protein Kibra acts upstream of Hippo in Drosophila.果蝇中 WW 结构域蛋白 Kibra 在上游作用于 Hippo。
Dev Cell. 2010 Feb 16;18(2):309-16. doi: 10.1016/j.devcel.2009.12.013.
9
Kibra is a regulator of the Salvador/Warts/Hippo signaling network.Kibra 是 Salvador/Warts/Hippo 信号通路的调节因子。
Dev Cell. 2010 Feb 16;18(2):300-8. doi: 10.1016/j.devcel.2009.12.011.
10
Kibra functions as a tumor suppressor protein that regulates Hippo signaling in conjunction with Merlin and Expanded.Kibra 作为一种肿瘤抑制蛋白，与 Merlin 和 Expanded 一起调节 Hippo 信号通路。
Dev Cell. 2010 Feb 16;18(2):288-99. doi: 10.1016/j.devcel.2009.12.012.

Hippo 通路在果蝇成体中肠再生过程中调节肠道干细胞增殖。

The Hippo pathway regulates intestinal stem cell proliferation during Drosophila adult midgut regeneration.

机构信息

Apoptosis and Proliferation Control Laboratory, Cancer Research UK, London Research Institute, 44 Lincoln's Inn Fields, London, WC2A 3LY, UK.

出版信息

Development. 2010 Dec;137(24):4147-58. doi: 10.1242/dev.052506. Epub 2010 Nov 10.

DOI:10.1242/dev.052506
PMID:21068063
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2990206/
Abstract

Intestinal stem cells (ISCs) in the adult Drosophila midgut proliferate to self-renew and to produce differentiating daughter cells that replace those lost as part of normal gut function. Intestinal stress induces the activation of Upd/Jak/Stat signalling, which promotes intestinal regeneration by inducing rapid stem cell proliferation. We have investigated the role of the Hippo (Hpo) pathway in the Drosophila intestine (midgut). Hpo pathway inactivation in either the ISCs or the differentiated enterocytes induces a phenotype similar to that observed under stress situations, including increased stem cell proliferation and expression of Jak/Stat pathway ligands. Hpo pathway targets are induced by stresses such as bacterial infection, suggesting that the Hpo pathway functions as a sensor of cellular stress in the differentiated cells of the midgut. In addition, Yki, the pro-growth transcription factor target of the Hpo pathway, is required in ISCs to drive the proliferative response to stress. Our results suggest that the Hpo pathway is a mediator of the regenerative response in the Drosophila midgut.

摘要

成年果蝇肠道中的肠干细胞 (ISCs) 增殖以自我更新，并产生分化的子细胞，以替代作为正常肠道功能一部分而丢失的细胞。肠道应激会激活 Upd/Jak/Stat 信号通路，该信号通路通过诱导快速的干细胞增殖来促进肠道再生。我们研究了 Hippo (Hpo) 途径在果蝇肠道 (中肠) 中的作用。在 ISCs 或分化的肠细胞中失活 Hpo 途径会诱导出类似于应激情况下观察到的表型，包括增加干细胞增殖和 Jak/Stat 途径配体的表达。Hpo 途径的靶标被细菌感染等应激诱导，这表明 Hpo 途径在中肠的分化细胞中作为细胞应激的传感器发挥作用。此外，Hpo 途径的促生长转录因子靶标 Yki 在 ISCs 中被需要以驱动对应激的增殖反应。我们的结果表明，Hpo 途径是果蝇中肠再生反应的介导者。