他汀类药物治疗狼疮介导的动脉粥样硬化形成：一石二鸟？
Statin therapy in lupus-mediated atherogenesis: two birds with one stone?
机构信息
Department of Vascular Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
出版信息
Ann Rheum Dis. 2011 Feb;70(2):245-8. doi: 10.1136/ard.2010.133827. Epub 2010 Nov 10.
Abstract
The atherosclerotic process is accelerated in patients with systemic lupus erythematosus (SLE). In addition to a robust lipid-lowering effect, various immunomodulatory functions have been ascribed to statins. By virtue of the latter they may be able to reduce atherosclerotic vascular disease in SLE by inhibiting immune activation within the arterial wall and by attenuating lupus activity. The effects of statins on SLE as well as on lupus-mediated atherogenesis in vivo are discussed in this viewpoint.
摘要
动脉粥样硬化进程在系统性红斑狼疮（SLE）患者中加速。除了强大的降脂作用外，他汀类药物还具有多种免疫调节功能。凭借后者，它们可以通过抑制动脉壁内的免疫激活和减轻狼疮活动来减少 SLE 中的动脉粥样硬化性血管疾病。本文从这一观点出发，讨论了他汀类药物对 SLE 以及狼疮介导的体内动脉粥样硬化形成的影响。
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