Department of Neurosciences, Beckman Research Institute of City of Hope, Duarte, California 91010, USA.
J Neurosci. 2010 Nov 10;30(45):14931-6. doi: 10.1523/JNEUROSCI.4280-10.2010.
MicroRNAs are a class of small RNA regulators that are involved in numerous cellular processes, including development, proliferation, differentiation, and plasticity. The emerging concept is that microRNAs play a central role in controlling the balance between stem cell self-renewal and fate determination by regulating the expression of stem cell regulators. This review will highlight recent advances in the regulation of neural stem cell self-renewal and neurogenesis by microRNAs. It will cover microRNA functions during the entire process of neurogenesis, from neural stem cell self-renewal and fate determination to neuronal maturation, synaptic formation, and plasticity. The interplay between microRNAs and both cell-intrinsic and -extrinsic stem cell players, including transcription factors, epigenetic regulators, and extrinsic signaling molecules will be discussed. This is a summary of the topics covered in the mini-symposium on microRNA regulation of neural stem cells and neurogenesis in SFN 2010 and is not meant to be a comprehensive review of the subject.
MicroRNAs 是一类参与众多细胞过程的小 RNA 调节剂，包括发育、增殖、分化和可塑性。新兴的概念是，microRNAs 通过调节干细胞调节剂的表达，在控制干细胞自我更新和命运决定之间的平衡方面发挥核心作用。本综述将重点介绍 microRNAs 对神经干细胞自我更新和神经发生的调控的最新进展。它将涵盖 microRNA 在神经发生的整个过程中的功能，从神经干细胞的自我更新和命运决定到神经元成熟、突触形成和可塑性。将讨论 microRNAs 与细胞内和细胞外干细胞参与者（包括转录因子、表观遗传调节剂和细胞外信号分子）之间的相互作用。这是在 2010 年 SFN 上关于 microRNA 调节神经干细胞和神经发生的小型专题研讨会涵盖的主题的总结，并非该主题的全面综述。
