miRNAs 和表观遗传学在神经干细胞命运决定中的作用。
Role of miRNAs and epigenetics in neural stem cell fate determination.
机构信息
Yale Cardiovascular Research Center; Section of Cardiovascular Medicine; Yale University School of Medicine; New Haven, CT USA.
出版信息
Epigenetics. 2014 Jan;9(1):90-100. doi: 10.4161/epi.27536. Epub 2013 Dec 16.
Abstract
The regulation of gene expression that determines stem cell fate determination is tightly controlled by both epigenetic and posttranscriptional mechanisms. Indeed, small non-coding RNAs such as microRNAs (miRNAs) are able to regulate neural stem cell fate by targeting chromatin-remodeling pathways. Here, we aim to summarize the latest findings regarding the feedback network of epigenetics and miRNAs during embryonic and adult neurogenesis.
摘要
调控基因表达决定干细胞命运的机制受到表观遗传和转录后机制的严格控制。事实上，微小 RNA（miRNA）等小非编码 RNA 能够通过靶向染色质重塑途径来调节神经干细胞命运。在这里，我们旨在总结胚胎和成年神经发生过程中表观遗传学和 miRNA 之间反馈网络的最新发现。
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