INRA, UMR 1019, UNH, CRNH Auvergne, Clermont-Ferrand, France.
Am J Clin Nutr. 2011 Jan;93(1):73-80. doi: 10.3945/ajcn.110.004945. Epub 2010 Nov 10.
Although numerous human studies have shown consistent effects of some polyphenol-rich foods on several intermediate markers for cardiovascular diseases, it is still unknown whether their action could be specifically related to polyphenols.
We investigated the effect of orange juice and its major flavonoid, hesperidin, on microvascular reactivity, blood pressure, and cardiovascular risk biomarkers through both postprandial and chronic intervention studies.
Twenty-four healthy, overweight men (age 50-65 y) were included in a randomized, controlled, crossover study. Throughout the three 4-wk periods, volunteers daily consumed 500 mL orange juice, 500 mL control drink plus hesperidin (CDH), or 500 mL control drink plus placebo (CDP). All measurements and blood collections were performed in overnight-fasted subjects before and after the 4-wk treatment periods. The postprandial study was conducted at the beginning of each experimental period.
Diastolic blood pressure (DBP) was significantly lower after 4 wk consumption of orange juice or CDH than after consumption of CDP (P = 0.02), whereas microvascular endothelium-related reactivity was not significantly affected when measured after an overnight fast. However, both orange juice and CDH ingestion significantly improved postprandial microvascular endothelial reactivity compared with CDP (P < 0.05) when measured at the peak of plasma hesperetin concentration.
In healthy, middle-aged, moderately overweight men, orange juice decreases DBP when regularly consumed and postprandially increases endothelium-dependent microvascular reactivity. Our study suggests that hesperidin could be causally linked to the beneficial effect of orange juice. This trial is registered at clinicaltrials.gov as NCT00983086.
虽然许多人体研究表明，一些富含多酚的食物对几种心血管疾病的中间标志物有一致的影响，但它们的作用是否与多酚有关仍不清楚。
我们通过餐后和慢性干预研究，研究橙汁及其主要类黄酮橙皮苷对微血管反应性、血压和心血管风险生物标志物的影响。
24 名健康、超重的男性（年龄 50-65 岁）被纳入一项随机、对照、交叉研究。在三个 4 周的治疗期间，志愿者每天饮用 500 毫升橙汁、500 毫升对照饮料加橙皮苷（CDH）或 500 毫升对照饮料加安慰剂（CDP）。所有测量和血液采集均在过夜禁食的受试者中进行，在 4 周治疗期前后进行。餐后研究在每个实验期开始时进行。
与 CDP 相比，4 周饮用橙汁或 CDH 后舒张压（DBP）明显降低（P = 0.02），而空腹时测量的微血管内皮相关反应性无明显变化。然而，与 CDP 相比，橙汁和 CDH 摄入均可显著改善餐后微血管内皮反应性，当在橙皮苷血浆浓度峰值时测量时（P < 0.05）。
在健康、中年、超重的男性中，定期饮用橙汁可降低 DBP，餐后可增加内皮依赖性微血管反应性。我们的研究表明，橙皮苷可能与橙汁的有益作用有关。该试验在 clinicaltrials.gov 上注册为 NCT00983086。
