Iwasaku-Fujimoto M, Fujiwara F, Todo S, Morioka Y, Imashuku S
Dept. of Pediatrics, Children's Research Hospital, Kyoto Prefectural University of Medicine.
Gan To Kagaku Ryoho. 1990 Mar;17(3 Pt 1):403-6.
We studied the efficacy of mesna as a protectant for urotoxicity in pediatric patients receiving chemotherapy including oxazaphosphorines. Nineteen patients with malignant diseases (5 neuroblastoma, 3 acute lymphocytic leukemia, 4 acute non-lymphocytic leukemia, 2 non-Hodgkin lymphoma, 3 osteosarcoma and 2 rhabdomyosarcoma) were treated with a total of 106 courses of therapy between June of 1986 and May of 1989. Of these, no gross hematuria were seen. Microhematuria transiently occurred only in 2 courses (5%) of 1 patient (2%). These data indicated that mesna was highly effective for urotoxicity of oxazaphosphorines without any side effects, especially in pediatric patients.
我们研究了美司钠作为接受包括氧氮磷啶类化疗药物的儿科患者尿路毒性保护剂的疗效。1986年6月至1989年5月期间，19例恶性疾病患者（5例神经母细胞瘤、3例急性淋巴细胞白血病、4例急性非淋巴细胞白血病、2例非霍奇金淋巴瘤、3例骨肉瘤和2例横纹肌肉瘤）共接受了106个疗程的治疗。其中，未观察到肉眼血尿。仅1例患者（2%）的2个疗程（5%）出现了短暂性镜下血尿。这些数据表明，美司钠对氧氮磷啶类药物的尿路毒性非常有效，且无任何副作用，尤其适用于儿科患者。
