Burkert H
Cancer Treat Rev. 1983 Sep;10 Suppl A:175-81. doi: 10.1016/s0305-7372(83)80026-7.
Mesna is superior to standard prophylaxis in inhibiting the urotoxicity of oxazaphosphorines. Mesna does not interfere with the antitumour effect of oxazaphosphorines and other cytostatics. Mesna is well tolerated. Mesna can be given orally. Mesna should be administered with each ifosfamide treatment and with high dose cyclophosphamide. It should also be given to any patient who may be at risk of developing cystitis following oxazaphosphorine treatment.
美司钠在抑制氧氮磷啶类药物的尿路毒性方面优于标准预防措施。美司钠不干扰氧氮磷啶类药物和其他细胞抑制剂的抗肿瘤作用。美司钠耐受性良好。美司钠可口服给药。每次给予异环磷酰胺治疗以及大剂量环磷酰胺时均应给予美司钠。对于任何在接受氧氮磷啶类药物治疗后可能有发生膀胱炎风险的患者也应给予美司钠。
