Lesbre J P, Bertrand S, Tribouilloy C, Mertl C, Choquet D, Remond A
CHU Amiens.
Arch Mal Coeur Vaiss. 1990 Feb;83(2):183-90.
The aim of this study was to assess the results of percutaneous aortic valvuloplasty in 50 patients (29 men and 21 women, mean age 74 years) at 6 months by Doppler echocardiography performed 24 hours before, 24 hours, 3 and 6 months after the procedure. The following parameters were compared: maximum instantaneous transaortic pressure gradient; mean gradient; aortic valve area and index of valve patency. The initial results of catheterisation and valvuloplasty were very satisfactory as the peak-to-peak and mean pressure gradients decreased by 50 per cent and the aortic valve area increased from 0.55 +/- 0.2 to 0.83 +/- 0.30 cm2 and the success rate defined as a final surface area greater than 0.75 cm2 was 84 per cent. Unfortunately, these favourable results were not sustained in most cases: restenosis, defined as a valve area of less than 0.7 cm2, was observed in 18 per cent of patients at Day 1 and 71 per cent of patients at the 6th month; the natural history of disease was little affected with a global mortality rate at 6 months of 18 per cent through cardiac failure and sudden death; only 18 per cent of patients maintained an aortic valve area of over 0.75 cm2 at 6 months. These results suggest that percutaneous aortic valvuloplasty should be reserved for patients in whom surgery is formally contra-indicated.
本研究的目的是通过在经皮主动脉瓣成形术之前24小时、术后24小时、3个月和6个月进行的多普勒超声心动图,评估50例患者(29例男性和21例女性,平均年龄74岁)在6个月时的经皮主动脉瓣成形术结果。比较了以下参数:最大瞬时跨主动脉压力梯度;平均梯度;主动脉瓣面积和瓣膜通畅指数。导管插入术和瓣膜成形术的初始结果非常令人满意,因为峰峰值和平均压力梯度下降了50%,主动脉瓣面积从0.55±0.2增加到0.83±0.30平方厘米,定义为最终表面积大于0.75平方厘米的成功率为84%。不幸的是,这些良好结果在大多数情况下未能持续:再狭窄定义为瓣膜面积小于0.7平方厘米,在第1天18%的患者中观察到,在第6个月71%的患者中观察到;疾病的自然病程几乎未受影响,6个月时因心力衰竭和猝死导致的总死亡率为18%;6个月时只有18%的患者主动脉瓣面积维持在0.75平方厘米以上。这些结果表明,经皮主动脉瓣成形术应仅用于手术存在明确禁忌的患者。