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经皮主动脉瓣成形术作为重症主动脉瓣狭窄患者的最后治疗手段

[Percutaneous aortic valvuloplasty as a last resort in patients with critical aortic valve stenosis].

作者信息

Cribier A, Lafont A, Eltchaninoff H, Gamra H, Koning R, Tron C, Letac B

机构信息

Service de cardiologie, centre hospitalo-universitaire, hôpital Charles-Nicolle, Rouen.

出版信息

Arch Mal Coeur Vaiss. 1990 Nov;83(12):1783-90.

PMID:2125188
Abstract

Emergency aortic valvuloplasty was performed as a last resort in 34 patients with an average age of 76 years with critical aortic stenosis in the terminal stages with congestive cardiac failure or cardiogenic shock. Emergency aortic valve replacement was considered to be too risky in these cases. The valve was dilated in all patients, resulting in a fall in mean peak-to-peak pressure gradients from 59 mmHg to 21 mmHg and an increase in valve surface area from 0.42 cm2 to 0.85 cm2. Significant improvement in myocardial function was observed immediately after the procedure with an increase of the cardiac index from 1.77 l/min/m2 to 2.07 l/min/m2 and of the ejection fraction from 28% to 35%. Complications were rare. There were no deaths or cerebrovascular accidents during the valvuloplasty procedure. Two patients died in hospital (6%) after the dilatation and two other patients who had persistent pulmonary oedema, underwent surgery; one died and the other had a good surgical result. A clear cut clinical improvement was obtained in the other 30 patients. The patients were followed up for an average of 15 +/- 7 months during which 15 died (50%), 6 +/- 5 months after dilatation. The other 15 survivors have a significant and unhoped for functional improvement. Three young patients later underwent surgical valve replacement in good clinical conditions with the same operative risk as that of standard candidates for aortic valve surgery. One other patient was operated on successfully during another relapse of cardiac failure. These results show that aortic valvuloplasty may be undertaken with a low risk even in the most critical clinical situations and that the procedure rapidly relieves the invalidating symptoms. It may be used as a bridge to surgery in patients with an unacceptable operative risk. The indications should be very flexible in young patients in terminal cardiac failure with cardiogenic shock or refractory pulmonary oedema.

摘要

34例平均年龄76岁、处于终末期且伴有充血性心力衰竭或心源性休克的严重主动脉瓣狭窄患者,作为最后的手段接受了急诊主动脉瓣成形术。在这些病例中,急诊主动脉瓣置换术被认为风险过高。所有患者的瓣膜均进行了扩张,平均跨瓣压差从59 mmHg降至21 mmHg,瓣膜面积从0.42 cm²增加至0.85 cm²。术后心肌功能立即有显著改善,心脏指数从1.77 l/min/m²增加至2.07 l/min/m²,射血分数从28%增加至35%。并发症罕见。瓣膜成形术过程中无死亡或脑血管意外发生。扩张术后2例患者在医院死亡(6%),另外2例持续存在肺水肿的患者接受了手术,其中1例死亡,另1例手术效果良好。其他30例患者有明显的临床改善。患者平均随访15±7个月,在此期间15例死亡(50%),在扩张术后6±5个月。另外15例存活患者有显著且出乎意料的功能改善。3例年轻患者后来在良好的临床状态下接受了外科瓣膜置换术,手术风险与主动脉瓣手术的标准候选者相同。另有1例患者在心力衰竭再次发作时成功接受了手术。这些结果表明,即使在最危急的临床情况下,主动脉瓣成形术也可以在低风险下进行,并且该手术能迅速缓解致残症状。它可以作为手术风险不可接受的患者的手术桥梁。对于终末期心力衰竭伴心源性休克或难治性肺水肿的年轻患者,适应证应非常灵活。

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