RADAR Task Group of Society of Nuclear Medicine, and Vanderbilt University, Nashville, TN 37232-2675, USA.
Health Phys. 2010 Dec;99(6):811-3. doi: 10.1097/HP.0b013e3181e47b33.
Three models for the biodistribution and dosimetry of 82Rb-chloride were reviewed and a proposal is made for the best dosimetry for this agent to be adopted. Data from three proposed biokinetic models for 82Rb-chloride were used to calculate dose estimates for the compound, and the results were compared. The blood content-based model was found to produce dose estimates that were considered to be overly conservative, and a blood flow-based model, which showed good agreement with available measured data, was considered to be more reasonable. A new set of dose estimates for 82Rb-chloride, based on the blood flow-based kinetic model are suggested for general use.
三种 82Rb 氯化物的生物分布和剂量学模型进行了回顾，并提出了该药物的最佳剂量学方案。使用三种拟议的 82Rb 氯化物生物动力学模型的数据来计算该化合物的剂量估算，并进行了比较。基于血液含量的模型被发现产生的剂量估算被认为过于保守，而基于血流的模型与现有测量数据吻合较好，被认为更为合理。建议使用基于血流动力学模型的新的 82Rb 氯化物剂量估算值作为一般用途。
