Department of Nuclear Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Hermes Medical Solutions, Stockholm, Sweden.
Eur J Nucl Med Mol Imaging. 2024 Jun;51(7):1869-1875. doi: 10.1007/s00259-024-06660-7. Epub 2024 Feb 26.
Long axial field-of-view (LAFOV) positron emission tomography (PET) systems allow to image all major organs with one bed position, which is particularly useful for acquiring whole-body dynamic data using short-lived radioisotopes like Rb.
We determined the absorbed dose in target organs of three subjects (29, 40, and 57 years old) using two different methods, i.e., MIRD and voxel dosimetry. The subjects were injected with 407.0 to 419.61 MBq of [Rb]Cl and were scanned dynamically for 7 min with a LAFOV PET/CT scanner.
Using the MIRD formalism and voxel dosimetry, the absorbed dose ranged from 1.84 to 2.78 μGy/MBq (1.57 to 3.92 μGy/MBq for voxel dosimetry) for the heart wall, 2.76 to 5.73 μGy/MBq (3.22 to 5.37 μGy/MBq for voxel dosimetry) for the kidneys, and 0.94 to 1.88 μGy/MBq (0.98 to 1.92 μGy/MBq for voxel dosimetry) for the lungs. The total body effective dose lied between 0.50 and 0.76 μSv/MBq.
Our study suggests that the radiation dose associated with [Rb]Cl PET/CT can be assessed by means of dynamic LAFOV PET and that it is lower compared to literature values.
长轴向视野（LAFOV）正电子发射断层扫描（PET）系统允许在一个床位位置对所有主要器官进行成像，这对于使用像 Rb 这样的短寿命放射性同位素获取全身动态数据特别有用。
我们使用两种不同的方法，即 MIRD 和体素剂量学，来确定三名受试者（29、40 和 57 岁）的靶器官吸收剂量。受试者注射[Rb]Cl 的量为 407.0 到 419.61MBq，并使用 LAFOV PET/CT 扫描仪进行 7 分钟的动态扫描。
使用 MIRD 公式和体素剂量学，心脏壁的吸收剂量范围为 1.84 到 2.78 μGy/MBq（体素剂量学为 1.57 到 3.92 μGy/MBq），肾脏的吸收剂量范围为 2.76 到 5.73 μGy/MBq（体素剂量学为 3.22 到 5.37 μGy/MBq），肺部的吸收剂量范围为 0.94 到 1.88 μGy/MBq（体素剂量学为 0.98 到 1.92 μGy/MBq）。全身有效剂量介于 0.50 和 0.76 μSv/MBq 之间。
我们的研究表明，[Rb]Cl PET/CT 相关的辐射剂量可以通过动态 LAFOV PET 来评估，并且与文献值相比，其剂量较低。
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