Altshuler L L, Devinsky O, Post R M, Theodore W
Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, Md.
Arch Neurol. 1990 Mar;47(3):284-8. doi: 10.1001/archneur.1990.00530030050016.
The association between anxiety, depression, and lateralization of an epileptogenic focus was explored in 18 adult patients with a left temporal lobe focus, 21 with a right focus, 20 with bilateral temporal foci, and 16 individuals with absence seizures. No significant difference in the level of anxiety was found among the groups. However, patients with left-sided temporal lobe epilepsy scored significantly higher than other groups on self-ratings for depression. This could not be accounted for by factors such as duration of epilepsy, employment status, education, age at seizure onset, or medication status. The left temporal lobe epilepsy group had a nonsignificantly larger number of males and left-handed subjects. The possible interactions between gender, handedness, seizure focus, and vulnerability to depression are described.
对18名左侧颞叶病灶的成年患者、21名右侧病灶患者、20名双侧颞叶病灶患者以及16名失神发作患者，探讨了焦虑、抑郁与致痫灶偏侧化之间的关联。各组间焦虑水平未发现显著差异。然而，左侧颞叶癫痫患者在抑郁自评方面的得分显著高于其他组。这无法用癫痫病程、就业状况、教育程度、癫痫发作起始年龄或用药状况等因素来解释。左侧颞叶癫痫组的男性和左利手受试者数量略多，但差异不显著。文中描述了性别、利手、癫痫病灶与抑郁易感性之间可能的相互作用。
