神经胶质细胞和神经元对脑血流的控制。
Glial and neuronal control of brain blood flow.
机构信息
Department of Neuroscience, Physiology and Pharmacology, University College London, Gower Street, London WC1E 6BT, UK.
出版信息
Nature. 2010 Nov 11;468(7321):232-43. doi: 10.1038/nature09613.
Abstract
Blood flow in the brain is regulated by neurons and astrocytes. Knowledge of how these cells control blood flow is crucial for understanding how neural computation is powered, for interpreting functional imaging scans of brains, and for developing treatments for neurological disorders. It is now recognized that neurotransmitter-mediated signalling has a key role in regulating cerebral blood flow, that much of this control is mediated by astrocytes, that oxygen modulates blood flow regulation, and that blood flow may be controlled by capillaries as well as by arterioles. These conceptual shifts in our understanding of cerebral blood flow control have important implications for the development of new therapeutic approaches.
摘要
大脑中的血液流动由神经元和星形胶质细胞调节。了解这些细胞如何控制血液流动对于理解神经计算如何供电、解释大脑功能成像扫描以及开发神经紊乱治疗方法至关重要。现在人们认识到，神经递质介导的信号在调节脑血流中起着关键作用，这种控制很大程度上是由星形胶质细胞介导的，氧调节血流调节，并且血流可能由毛细血管以及小动脉控制。这些我们对脑血流控制的理解上的概念转变对新的治疗方法的发展具有重要意义。
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