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对神经疾病的分子机制及其病理生理反应的见解。

Insights into the molecular mechanism of neurological diseases and their pathophysiological responses.

作者信息

Banerjee Sharmistha, Sil Parames C

机构信息

Centre for Research in Pure and Applied Sciences, Jain University, Bengaluru, Karnakata, 560078, India.

Division of Molecular Medicine, Bose Institute, P-1/12, CIT Scheme VII M, Kolkata, West Bengal, 700054, India.

出版信息

Arch Toxicol. 2025 Sep 13. doi: 10.1007/s00204-025-04181-2.

Abstract

The origin of neurological disorders and their associated symptoms have been known for a very long time tracing to the origin of human being. However, the detailed mechanism at the molecular level came to existence after intensive research for decades. This review aims to discuss the molecular mechanisms responsible for the onset till the progression of these diseases casting its role at cellular, organelles, and metal ions level. Advanced microscopic techniques enabled correlation of pathological responses at ultrastructural level that is helpful if coupled with biochemical parameters. The review also sheds a glimpse of focus on creative movements to improve cognition in neurodegenerative patients as a part of therapy.

摘要

神经系统疾病及其相关症状的起源可以追溯到人类起源,人们对此已经了解很长时间了。然而,经过数十年的深入研究,分子水平的详细机制才得以揭示。本综述旨在探讨这些疾病从发病到进展过程中在细胞、细胞器和金属离子水平发挥作用的分子机制。先进的显微镜技术能够在超微结构水平上关联病理反应,若与生化参数相结合则更有帮助。本综述还简要介绍了作为治疗一部分的旨在改善神经退行性疾病患者认知的创新性举措。

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