An electrospray/inductively coupled plasma dual-source time-of-flight mass spectrometer for rapid metallomic and speciation analysis. Part 2. Atomic channel and dual-channel characterization.

A new Time-of-Flight Mass Spectrometer (TOFMS) has been developed that employs an electrospray source and an inductively coupled plasma simultaneously to provide molecular, structural, atomic, and isotopic information from a sample. This paper will focus on characterization of the ICP source and will demonstrate simultaneous operation of the two sources. Preliminary sensitivities and limits of detection for Cr, Co, Ga, As, Ag, Cs, Ho, Hg, Tl, and Bi on the ICP channel are reported. Long-term stability and drift of the ICP channel are also discussed. Simultaneous operation of both channels is demonstrated for cyanocobalamin, myoglobin, and superoxide dismutase.