Department of Biochemistry, International Centre for Cardiothoracic and Vascular Diseases, Dr. K. M. Cherian Heart Foundation (a unit of Frontier LifeLine Pvt Ltd), R-30 C Ambattur Industrial Estate Road, Mogaippair, Chennai, India.
Biochem Genet. 2011 Feb;49(1-2):96-103. doi: 10.1007/s10528-010-9391-7. Epub 2010 Nov 11.
In an analysis of the possible association of endothelial constitutive nitric oxide synthase (ecNOS) gene polymorphism and plasma nitric oxide levels in patients with acute coronary syndrome, we investigated 106 patients with the syndrome and 100 healthy controls. Genotype was determined using the polymerase chain reaction; plasma nitric oxide levels were found using ELISA. The genotype frequencies for the a/b polymorphism in the control group were 77% for bb, 19% for ab, and 4% for aa. In the patients, genotype frequencies were 55% bb, 34% ab, and 11% aa. The allele frequencies were 28% a and 72% b among the patients and 13% a and 87% b among control subjects. Our findings showed a significant association of the ecNOS gene polymorphism with acute coronary syndrome in the South Indian population.
在分析内皮型一氧化氮合酶（ecNOS）基因多态性与急性冠状动脉综合征患者血浆一氧化氮水平之间可能存在的关联时，我们调查了 106 例综合征患者和 100 例健康对照者。采用聚合酶链反应确定基因型；采用 ELISA 法检测血浆一氧化氮水平。对照组中 a/b 多态性的基因型频率分别为 bb 77%、ab 19%和 aa 4%。在患者中，基因型频率分别为 bb 55%、ab 34%和 aa 11%。等位基因频率分别为患者中的 a 28%和 b 72%，以及对照中的 a 13%和 b 87%。我们的研究结果表明，ecNOS 基因多态性与南印度人群中的急性冠状动脉综合征显著相关。
