Dermatology II Department, University Hospital Central of Asturias (HUCA), 33007, Oviedo, Spain.
Arch Dermatol Res. 2011 Aug;303(6):445-9. doi: 10.1007/s00403-011-1129-9. Epub 2011 Feb 4.
Nitric oxide (NO) is a potent regulator of keratinocyte growth and differentiation that has been implicated in the pathogenesis of psoriasis (Ps). The NOS3 -786 T/C (SNP id rs2070744; http://www.ensembl.org ), intron 4 variable number tandem repeat (VNTR), and Glu298Asp (SNP id rs1799983) polymorphisms, have been associated with differences in NO plasma concentrations and with the risk of hypertension (HT) and ischemic cardiac disease. The aim of this study was to determine whether the above-mentioned NOS3 variants contributed to the risk of Ps, and were associated with the risk for HT and CAD in these patients. A total of 368 patients with chronic plaque Ps and 400 healthy controls were genotyped for the NOS3 -786 T/C, intron 4 VNTR, and Glu298Asp polymorphisms. Carriers of the -786 C allele were significantly more frequent among the patients (p < 0.001). Carriers of the 4-repeats allele (45 + 44 genotypes) were also more frequent a (p < 0.001). No significant difference was found for the Glu298Asp polymorphism. None of the NOS3 variants was associated with Ht and CAD in our population. In conclusion, NOS3 gene polymorphism would be risk factors for developing Ps.
一氧化氮（NO）是一种强有力的角质形成细胞生长和分化调节剂，它与银屑病（Ps）的发病机制有关。NOS3-786T/C（SNP 编号 rs2070744；http://www.ensembl.org）、内含子 4 可变数目串联重复（VNTR）和 Glu298Asp（SNP 编号 rs1799983）多态性与血浆中 NO 浓度的差异以及高血压（HT）和缺血性心脏病的风险相关。本研究的目的是确定上述 NOS3 变体是否会增加患 Ps 的风险，以及是否与这些患者发生 HT 和 CAD 的风险相关。共对 368 例慢性斑块型 Ps 患者和 400 名健康对照者进行了 NOS3-786T/C、内含子 4VNTR 和 Glu298Asp 多态性的基因分型。患者中-786C 等位基因的携带者明显更为常见（p<0.001）。携带 4 个重复等位基因（45+44 基因型）的患者也更为常见（p<0.001）。Glu298Asp 多态性无显著差异。在我们的人群中，NOS3 变体均与 HT 和 CAD 无关。综上所述，NOS3 基因多态性可能是患 Ps 的危险因素。
