Department of Vascular Surgery, Beaumont Hospital, Beaumont Road, Beaumont, Dublin 9, Ireland.
Ir J Med Sci. 2011 Jun;180(2):375-8. doi: 10.1007/s11845-010-0513-3. Epub 2010 Nov 11.
Abdominal aortic aneurysm (AAA) surgery provides a unique opportunity to study the impact of arterial stiffness on central haemodynamics, reflected in augmentation index (AI). The aneurysmal aorta is significantly stiffer than undilated age-matched aorta.
We investigated whether replacement of an aneurysmal aorta with a compliant graft would result in a decrease in AI, which would thus decrease myocardial workload parameters.
Patients undergoing elective open or endovascular AAA repair were assessed with applanation tonometry and laser fluximetry pre-operatively, immediately and long-term post-operatively.
Replacement of a small segment of abnormal conduit vessel resulted in improvements in AI, demonstrating that arterial stiffness can be surgically manipulated.
These results reflect a decreased myocardial workload post-aortic grafting. This decrease in AI is important from a risk factor management perspective, and arterial stiffness should become a further recognised and screened for risk factor in patients with known aneurysmal disease.
腹主动脉瘤（AAA）手术为研究动脉僵硬度对中心血流动力学的影响提供了独特的机会，这种影响反映在增强指数（AI）上。与未扩张的年龄匹配的主动脉相比，动脉瘤样的主动脉明显更硬。
我们研究了用顺应性移植物替换动脉瘤样主动脉是否会导致 AI 降低，从而降低心肌工作量参数。
对接受择期开放或血管内 AAA 修复的患者进行术前、术后即刻和长期的平板压力测量和激光流量测量。
替换一小段异常的导管段可改善 AI，表明动脉僵硬度可以通过手术进行干预。
这些结果反映了主动脉移植术后心肌工作量的减少。从危险因素管理的角度来看，AI 的这种降低是很重要的，并且在已知动脉瘤性疾病的患者中，动脉僵硬度应该成为另一个被识别和筛查的危险因素。
