Paediatric Research Centre, University of Tampere and Department of Paediatrics, Tampere University Hospital, Tampere, Finland.
Ann Med. 2010 Dec;42(8):587-95. doi: 10.3109/07853890.2010.505931.
Although the prevalence of celiac disease (CD) has been extensively investigated in recent years, an accurate estimate of CD frequency in the European population is still lacking. The aims of this study were: 1) to establish accurately the prevalence of CD in a large sample of the European population (Finland, Germany, Italy, and UK), including both children and adults; and 2) to investigate whether the prevalence of CD significantly varies between different areas of the European continent.
Samples were drawn from the four populations. All 29,212 participants were tested for CD by tissue transglutaminase (tTG) antibody test. Positive and border-line findings were further tested for serum endomysial antibodies (EMA). All serological determinations were centrally performed. Small-bowel biopsies were recommended to autoantibody-positive individuals. Previously diagnosed cases were identified.
The overall CD prevalence (previously diagnosed plus anti-tTG and EMA positives) was 1.0% (95% CI 0.9-1.1). In subjects aged 30-64 years CD prevalence was 2.4% in Finland (2.0-2.8), 0.3% in Germany (0.1-0.4), and 0.7% in Italy (0.4-1.0). Sixty-eight percent of antibody-positive individuals showed small-bowel mucosal changes typical for CD (Marsh II/III lesion).
CD is common in Europe. CD prevalence shows large unexplained differences in adult age across different European countries.
尽管近年来对乳糜泻（CD）的患病率进行了广泛研究，但欧洲人群中 CD 频率的准确估计仍存在不足。本研究的目的是：1）在包括儿童和成人在内的欧洲大样本中准确确定 CD 的患病率；2）研究 CD 在欧洲大陆不同地区的患病率是否存在显著差异。
从四个群体中抽取样本。所有 29212 名参与者均通过组织转谷氨酰胺酶（tTG）抗体试验进行 CD 检测。阳性和边界线发现进一步通过血清内肌内膜抗体（EMA）进行检测。所有血清学测定均在中心进行。建议对自身抗体阳性者进行小肠活检。同时还确定了既往诊断的病例。
总体 CD 患病率（既往诊断病例加上抗 tTG 和 EMA 阳性者）为 1.0%（95%CI 0.9-1.1）。在 30-64 岁的人群中，芬兰的 CD 患病率为 2.4%（2.0-2.8），德国为 0.3%（0.1-0.4），意大利为 0.7%（0.4-1.0）。68%的抗体阳性者显示出典型的 CD 小肠黏膜变化（Marsh II/III 病变）。
CD 在欧洲很常见。在不同的欧洲国家，成人年龄的 CD 患病率存在较大的未解释差异。
