Lamy F, Lecocq R, Dumont J E
Ann Endocrinol (Paris). 1978;39(2):129-30.
It is now well established that cAMP is the intracellular mediator of many effects of thyrotropin on the thyroid. Greengard has postulated that all the effects of cAMP inside the cell are secondary to the phosphorylation of proteins by cAMP activated protein kinase(s). The purpose of our work is to define, in an intact cell system, the nature of the thyroid proteins, the phosphorylation of which is stimulated by cAMP and TSH.
现已充分证实，环磷酸腺苷（cAMP）是促甲状腺激素对甲状腺多种作用的细胞内介质。格林加德推测，细胞内cAMP的所有作用都是由cAMP激活的蛋白激酶使蛋白质磷酸化的继发性结果。我们这项工作的目的是在完整细胞系统中确定甲状腺蛋白的性质，其磷酸化受cAMP和促甲状腺激素（TSH）刺激。
