Singapore National Eye Centre, Singapore.
Clin Exp Ophthalmol. 2011 May-Jun;39(4):299-307. doi: 10.1111/j.1442-9071.2010.02458.x. Epub 2011 May 29.
To describe the demographics, clinical characteristics and visual function of Asian patients with keratoconus managed in a tertiary eye centre.
Prospective cross-sectional study.
116 patients with clinically evident or suspected keratoconus (on videokeratography) recruited over 11 months.
A standardised interview, full ophthalmic examination, refraction and corneal topography were performed. Visual function was assessed with the VF-14 questionnaire.
Demographics, clinical characteristics and visual function.
Mean age of our patients was 29.5 ± 9.40 years on enrolment, 62.9% were male, and the ethnic distribution was 60.3% Chinese, 13.8% Malays and 9.5% Indians. Clinically evident keratoconus was present bilaterally in 65 patients (56.0%) and unilateral keratoconus in five patients (4.3%). Five patients (4.3%) had a family history of keratoconus. The majority of patients were managed with contact lenses (60.8%) or glasses (24.5%). Eye rubbing was common (68%) as were asthma (26.3%) and eczema (18.4%). Conical protrusion was the commonest sign (75.3%). The mean cylinder was higher in keratoconus eyes compared with keratoconus suspect eyes (-4.01 vs. -1.27, P < 0.001), and best-corrected visual acuity was poorer (0.19 vs. 0.05, P < 0.001). Unaided visual acuity was significantly worse with increasing age (P = 0.016). On the VF-14, 32% scored 90 or less (out of 100), reflecting difficulties with vision-related daily activities.
Our Asian patients with keratoconus had similar demographic and clinical characteristics to patients in Western populations. Even with apparently good visual acuity, some patients still experience substantial impairment in vision-related activities.
描述在一家三级眼科中心接受治疗的亚洲圆锥角膜患者的人口统计学、临床特征和视觉功能。
前瞻性横断面研究。
在 11 个月的时间里，招募了 116 名经视频角膜地形图检查确诊或疑似患有圆锥角膜的患者。
进行了标准化访谈、全面眼科检查、验光和角膜地形图检查。使用 VF-14 问卷评估视觉功能。
人口统计学、临床特征和视觉功能。
纳入患者的平均年龄为 29.5±9.40 岁，62.9%为男性，种族分布为 60.3%为华人，13.8%为马来人，9.5%为印度人。65 名患者（56.0%）双侧存在临床明显的圆锥角膜，5 名患者（4.3%）单侧存在圆锥角膜。5 名患者（4.3%）有圆锥角膜家族史。大多数患者通过接触镜（60.8%）或眼镜（24.5%）进行治疗。揉眼很常见（68%），哮喘（26.3%）和湿疹（18.4%）也很常见。最常见的体征是圆锥突起（75.3%）。与圆锥角膜可疑眼相比，圆锥角膜眼的平均柱镜值更高（-4.01 与-1.27，P<0.001），最佳矫正视力更差（0.19 与 0.05，P<0.001）。未矫正视力随年龄增长而显著下降（P=0.016）。在 VF-14 中，32%的患者得分在 90 或以下（满分 100 分），这反映了他们在与视力相关的日常活动中存在困难。
我们的亚洲圆锥角膜患者与西方人群的患者具有相似的人口统计学和临床特征。即使视力明显较好，一些患者在与视力相关的活动中仍存在明显的障碍。
