Kelly R P, Gibbs H H, O'Rourke M F, Daley J E, Mang K, Morgan J J, Avolio A P
Cardiology Department, St Vincent's Hospital, Darlinghurst, New South Wales, Australia.
Eur Heart J. 1990 Feb;11(2):138-44. doi: 10.1093/oxfordjournals.eurheartj.a059669.
Nitroglycerin (0.3 mg) was administered sublingually to 14 patients undergoing cardiac catheterization, and pressure waves compared in the ascending aorta and brachial artery. After nitroglycerin, ascending aortic systolic pressure fell in all cases (by 6-44, average 22 mmHg) whereas brachial systolic pressure remained unchanged (in three) or fell to a lesser degree (4-33, average 12 mmHg). Diastolic pressure did not change significantly. Alterations in pressure and in wave contour were explained on the basis of arterial dilation, with reduction in wave reflection. Nitroglycerin reduces left ventricular afterload through arterial dilation as well as preload through venous dilation. This effect on afterload is not apparent from measurement of pressure in the brachial artery.
对14例接受心导管插入术的患者舌下含服硝酸甘油（0.3毫克），并比较升主动脉和肱动脉的压力波。含服硝酸甘油后，所有病例的升主动脉收缩压均下降（下降6 - 44，平均22毫米汞柱），而肱动脉收缩压保持不变（3例）或下降幅度较小（4 - 33，平均12毫米汞柱）。舒张压无明显变化。压力和波形轮廓的改变是基于动脉扩张及波反射减少来解释的。硝酸甘油通过动脉扩张降低左心室后负荷，并通过静脉扩张降低前负荷。这种对后负荷的影响从肱动脉压力测量中并不明显。
