Division of Environmental Health Sciences, School of Public Health, University of Minnesota, Mayo Mail Code #807, 420 Delaware Street SE, Minneapolis, MN 55455, USA.
Toxicon. 2011 Mar 1;57(3):440-8. doi: 10.1016/j.toxicon.2010.11.003. Epub 2010 Nov 9.
Although known for its acutely toxic action, palytoxin has also been identified as a type of carcinogenic agent called a tumor promoter. In general tumor promoters do not damage DNA, but instead contribute to carcinogenesis by disrupting the regulation of cellular signaling. The identification of palytoxin as a tumor promoter, together with the recognition that the Na(+), K(+)-ATPase is its receptor, led to research on how palytoxin triggers the modulation of signal transduction pathways. This review focuses on mitogen activated protein (MAP) kinases as mediators of palytoxin-stimulated signaling. MAP kinases are a family of serine/threonine kinases that relay a variety of signals to the cellular machinery that regulates cell fate and function. The studies discussed in this review investigated how palytoxin stimulates MAP kinase activity and, in turn, how MAP kinases mediate the response of cells to palytoxin.
尽管众所周知，它具有极强的毒性作用，但已确认它也是一种致癌物质，称为肿瘤促进剂。一般来说，肿瘤促进剂不会损害 DNA，而是通过破坏细胞信号转导的调节来促进致癌作用。将 palytoxin 鉴定为肿瘤促进剂，以及认识到 Na(+)，K(+)-ATPase 是其受体，导致了对 palytoxin 如何引发信号转导途径调制的研究。本综述重点介绍丝裂原激活蛋白 (MAP) 激酶作为 palytoxin 刺激信号的介质。MAP 激酶是一组丝氨酸/苏氨酸激酶，可将各种信号传递到调节细胞命运和功能的细胞机制。本综述中讨论的研究调查了 palytoxin 如何刺激 MAP 激酶活性，以及反过来，MAP 激酶如何介导细胞对 palytoxin 的反应。
