Department of Agriculture, Cattle farming and Derived products, High Institute of the Sahel, University of Maroua, Cameroon.
J Ethnopharmacol. 2011 Jan 27;133(2):773-9. doi: 10.1016/j.jep.2010.11.011. Epub 2010 Nov 9.
While the Hibiscus asper Hook.f. (Malvaceae) is a traditional herb largely used in tropical region of the Africa as vegetable, potent sedative, tonic and restorative, anti-inflammatory and antidepressive drug, there is very little scientific data concerning the efficacy of this.
We investigated antioxidant activity and the effects of methanolic extract of Hibiscus asper leaves on neurological capacity of male Wistar rats subjected to unilateral 6-hydroxydopamine (6-OHDA)-lesion.
Two model systems: 2,4-dinitrophenyl-1-picryl hydrazyl (DPPH) radical scavenging activity and β-carotene bleaching inhibition assay were used to measure the antioxidant activities of the plan extract. We also investigated the neuroprotective effect of methanolic extract of Hibiscus asper leaves (50 and 100 mg/kg) in male Wistar rats subjected to unilateral 6-hydroxydopamine (6-OHDA)-lesion rat model.
Methanolic extract of Hibiscus asper leaves showed potent antioxidant and free radical scavenging activity. Chronic administration of methanolic extract (50 and 100 mg/kg, i.p., daily, for 7 days) significantly reduce anxiety-like behavior and inhibit depression in elevated plus-maze and forced swimming tests, suggesting anxiolytic and antidepressant activity. Also, spatial memory performance in Y-maze and radial arm-maze tasks was improved, suggesting positive effects on memory formation.
Taken together, our results suggest that the methanolic extract of Hibiscus asper leaves have antioxidant effects and might provide an opportunity to management neurological abnormalities in Parkinson's disease conditions.
虽然芙蓉 asper Hook.f.（锦葵科）是一种传统草药，主要在非洲热带地区用作蔬菜、强效镇静剂、滋补品和恢复剂、消炎药和抗抑郁药，但关于其疗效的科学数据却很少。
我们研究了芙蓉 asper 叶甲醇提取物的抗氧化活性及其对单侧 6-羟多巴胺（6-OHDA）损伤雄性 Wistar 大鼠神经能力的影响。
使用 2,4-二硝基苯-1-苦基肼（DPPH）自由基清除活性和β-胡萝卜素漂白抑制测定法两种模型系统来测量植物提取物的抗氧化活性。我们还研究了芙蓉 asper 叶甲醇提取物（50 和 100 mg/kg）对单侧 6-羟多巴胺（6-OHDA）损伤雄性 Wistar 大鼠模型的神经保护作用。
芙蓉 asper 叶甲醇提取物表现出很强的抗氧化和自由基清除活性。慢性给予芙蓉 asper 叶甲醇提取物（50 和 100 mg/kg，腹腔注射，每天一次，连续 7 天）可显著减轻高架十字迷宫和强迫游泳试验中的焦虑样行为，并抑制抑郁，表明具有抗焦虑和抗抑郁活性。此外，Y 迷宫和放射臂迷宫任务中的空间记忆表现得到改善，表明对记忆形成有积极影响。
综上所述，我们的结果表明，芙蓉 asper 叶甲醇提取物具有抗氧化作用，可能为管理帕金森病患者的神经异常提供机会。
