氮平衡调控一瞥。

A glimpse at regulation of nitrogen homeostasis.

机构信息

School of Agriculture, Food, and Wine, The University of Adelaide, Glen Osmond, SA 5064, Australia.

出版信息

Structure. 2010 Nov 10;18(11):1395-7. doi: 10.1016/j.str.2010.10.003.

DOI:10.1016/j.str.2010.10.003

Abstract

NrpR is a 2-oxoglutarate (2OG)-sensing transcription factor found in the archaeal phylum euryarchaetoa. When 2OG concentrations are low, NrpR transcriptionally represses expression of the nitrogen acquisition genes. Structural studies by Wisedchaisri et al. (2010) have identified the cleft region, where 2OG binds to NrpR. Their study has highlighted conservation of 2OG-binding residues among other 2OG-responsive proteins.

摘要

NrpR 是一种 2-氧戊二酸（2OG）感应转录因子，存在于古菌门的广古菌中。当 2OG 浓度较低时，NrpR 转录抑制氮吸收基因的表达。Wisedchaisri 等人（2010 年）的结构研究确定了 2OG 与 NrpR 结合的裂隙区域。他们的研究强调了其他 2OG 反应蛋白中 2OG 结合残基的保守性。