Leukocyte Biology Section, National Heart and Lung Institute, Sir Alexander Fleming Building, Faculty of Medicine, Imperial College, South Kensington, London SW7 2AZ, UK.
Curr Opin Immunol. 2010 Dec;22(6):800-6. doi: 10.1016/j.coi.2010.10.006. Epub 2010 Nov 9.
The discovery of IL-33 as the ligand for the orphan Th2 associated receptor ST2 has uncovered a whole range of different avenues for this pathway. Although the extracellular functions of ST2 as a marker for Th2 cell and mast cell activity were well defined, the complexities of IL-33 regulation, nuclear function and secretion are only just being realised. The well documented expression pattern of ST2 has identified a role for the IL-33/ST2 axis in the classical Th2 cell and mast cell driven pathogenesis of asthma and anaphylaxis. However, the induction of IL-33 expression by environmental or endogenous triggers now suggests a wider role for the pathway during infection, inflammation and tissue damage.
IL-33 作为孤儿 Th2 相关受体 ST2 的配体被发现，为这条通路开辟了一系列不同的途径。虽然 ST2 的细胞外功能作为 Th2 细胞和肥大细胞活性的标志物已经得到很好的定义，但 IL-33 的调控、核功能和分泌的复杂性才刚刚开始被认识到。ST2 的表达模式已被充分记录，表明 IL-33/ST2 轴在哮喘和过敏反应的经典 Th2 细胞和肥大细胞驱动的发病机制中发挥作用。然而，环境或内源性触发物诱导 IL-33 表达表明，该通路在感染、炎症和组织损伤期间可能发挥更广泛的作用。
