Ten Kate R W, Tuynman H A, Festen H P, Pals G, Meuwissen S G
Department of Internal Medicine and Gastroenterology, Free University Hospital, Amsterdam, The Netherlands.
Hepatogastroenterology. 1990 Feb;37(1):124-7.
To investigate the effect of pentagastrin on serum and urinary pepsinogens and gastric pepsin, eight healthy male volunteers were studied twice during continuous intragastric perfusion with either NaCl 0.9% or 0.1 M HCl in random order. To the perfusate 3 mg/ml phenol red was added as inert recovery marker. Gastric content was aspirated in 15-minute samples, 4 basally and subsequently 6 during continuous i.v. infusion of pentagastrin 1.5 micrograms/kg/h. Furthermore, serum and urine samples were collected immediately before and after each test. Gastric pepsin output increased after pentagastrin. There were no differences in basal or stimulated pepsin output during saline or HCl perfusion despite marked differences in intra-gastric acidity and acid delivery to the duodenum. In addition, no significant changes in serum pepsinogen levels or urinary pepsinogen excretion were observed after pentagastrin infusion. It is concluded that pentagastrin stimulates gastric pepsin secretion directly, but does not stimulate the release of pepsinogens into the systemic circulation.
为研究五肽胃泌素对血清和尿胃蛋白酶原及胃蛋白酶的影响，8名健康男性志愿者以随机顺序在持续胃内灌注0.9%氯化钠溶液或0.1M盐酸期间接受了两次研究。向灌注液中添加3mg/ml酚红作为惰性回收标记物。每15分钟采集一次胃内容物样本，基础状态下采集4次，随后在持续静脉输注五肽胃泌素1.5微克/千克/小时期间采集6次。此外，在每次测试前后立即采集血清和尿液样本。五肽胃泌素注射后胃蛋白酶分泌量增加。尽管胃内酸度和酸向十二指肠的输送存在显著差异，但在生理盐水或盐酸灌注期间基础或刺激状态下的胃蛋白酶分泌量并无差异。此外，五肽胃泌素输注后未观察到血清胃蛋白酶原水平或尿胃蛋白酶原排泄有显著变化。研究得出结论，五肽胃泌素直接刺激胃蛋白酶分泌，但不刺激胃蛋白酶原释放进入体循环。
