Robinson James, Mistry Kavita, McWilliam Hamish, Lopez Rodrigo, Parham Peter, Marsh Steven G E
Anthony Nolan Research Institute, Royal Free Hospital, Pond Street, Hampstead, London NW3 2QG, UK.
Nucleic Acids Res. 2011 Jan;39(Database issue):D1171-6. doi: 10.1093/nar/gkq998. Epub 2010 Nov 11.
It is 12 years since the IMGT/HLA database was first released, providing the HLA community with a searchable repository of highly curated HLA sequences. The HLA complex is located within the 6p21.3 region of human chromosome 6 and contains more than 220 genes of diverse function. Many of the genes encode proteins of the immune system and are highly polymorphic. The naming of these HLA genes and alleles and their quality control is the responsibility of the WHO Nomenclature Committee for Factors of the HLA System. Through the work of the HLA Informatics Group and in collaboration with the European Bioinformatics Institute, we are able to provide public access to this data through the web site http://www.ebi.ac.uk/imgt/hla/. Regular updates to the web site ensure that new and confirmatory sequences are dispersed to the HLA community, and the wider research and clinical communities.
IMGT/HLA数据库首次发布至今已有12年，为HLA群体提供了一个可搜索的、经过高度整理的HLA序列储存库。HLA复合体位于人类6号染色体的6p21.3区域内，包含220多个功能各异的基因。其中许多基因编码免疫系统的蛋白质，并且具有高度多态性。这些HLA基因和等位基因的命名及其质量控制由世界卫生组织HLA系统因子命名委员会负责。通过HLA信息学小组的工作，并与欧洲生物信息学研究所合作，我们能够通过网站http://www.ebi.ac.uk/imgt/hla/向公众提供这些数据。该网站的定期更新确保新的和经过确认的序列能够传播给HLA群体以及更广泛的研究和临床群体。
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