Robinson James, Marsh Steven G E
Anthony Nolan Research Institute, Royal Free Hospital, Hampstead, London, UK.
Methods Mol Biol. 2007;409:43-60. doi: 10.1007/978-1-60327-118-9_3.
The human leukocyte antigen (HLA) complex is located within the 6p21.3 region on the short arm of human chromosome 6 and contains more than 220 genes of diverse function. Many of the genes encode proteins of the immune system and include many highly polymorphic HLA genes. The naming of new HLA genes and allele sequences and their quality control is the responsibility of the WHO Nomenclature Committee for Factors of the HLA System. The IMGT/HLA Database acts as the repository for these sequences and is recognized as the primary source of up-to-date and accurate HLA sequences. The IMGT/HLA website provides a number of tools for accessing the database: these include allele reports, sequence alignments, and sequence similarity searches. The website is updated every 3 months with all the new and confirmatory sequences submitted to the WHO Nomenclature Committee. Submission of HLA sequences to the committee is possible through the tools provided by the IMGT/HLA Database.
人类白细胞抗原（HLA）复合体位于人类6号染色体短臂的6p21.3区域内，包含220多个功能各异的基因。许多基因编码免疫系统的蛋白质，包括许多高度多态性的HLA基因。新HLA基因和等位基因序列的命名及其质量控制由世界卫生组织HLA系统因子命名委员会负责。IMGT/HLA数据库是这些序列的储存库，被公认为最新和准确HLA序列的主要来源。IMGT/HLA网站提供了许多访问该数据库的工具：包括等位基因报告、序列比对和序列相似性搜索。该网站每3个月更新一次，包含提交给世界卫生组织命名委员会的所有新的和确认的序列。通过IMGT/HLA数据库提供的工具可以向委员会提交HLA序列。
