Michaeli D, McPherson M
Department of Surgery, School of Medicine, University of California, San Francisco.
J Burn Care Rehabil. 1990 Jan-Feb;11(1):21-6. doi: 10.1097/00004630-199001000-00005.
Artificial skin (Integra) has been developed as an effective treatment of full-thickness burns. The material consists of a bovine collagen and chondroitin-6-sulfate dermal matrix with a silicone rubber "epidermal" layer. After burn wound excision, the artificial skin is implanted. Only the temporary silicone rubber epidermal membrane is removed. The dermal collagen matrix is incorporated by the host. Serial serum samples were obtained from patients who had grafts of Integra artificial skin for the determination of the humoral immune response to Integra. Integra artificial skin presents few if any humoral immunologic problems to patients. Increased antibody activity to bovine skin collagen, bovine skin collagen with chondroitin sulfate, and human skin collagen was not considered immunologically significant.
人工皮肤（Integra）已被开发用于全层烧伤的有效治疗。该材料由带有硅橡胶“表皮”层的牛胶原蛋白和硫酸软骨素-6-硫酸盐真皮基质组成。烧伤创面切除后，植入人工皮肤。仅去除临时的硅橡胶表皮膜。真皮胶原蛋白基质由宿主整合。从接受Integra人工皮肤移植的患者中获取系列血清样本，以测定对Integra的体液免疫反应。Integra人工皮肤给患者带来的体液免疫问题极少（如果有的话）。针对牛皮肤胶原蛋白、含硫酸软骨素的牛皮肤胶原蛋白和人皮肤胶原蛋白的抗体活性增加在免疫学上不被认为具有重要意义。
