Stern R, McPherson M, Longaker M T
University of California, San Francisco.
J Burn Care Rehabil. 1990 Jan-Feb;11(1):7-13. doi: 10.1097/00004630-199001000-00003.
Integra artificial skin is an effective means of treatment for full-thickness burns. In extensive burn injury the use of such skin substitutes may become the treatment of choice. The artificial skin consists of a dermal substitute of bovine collagen and chondroitin-6-sulfate and an epidermal layer of synthetic polysiloxane polymer (Silastic). Serial biopsy specimens were obtained from 131 patients during a period of 7 days to 2 years after application. In this histologic study, six sequential phases of repair were discerned. In addition, there were occasional unusual histologic features, eosinophilic infiltration, and/or macrophage-derived giant cell formation in the wound area; however, such findings did not clinically correlate with a negative response to Integra artificial skin. Good repair was obtained, with rare exceptions. An intact dermis was achieved as well as definitive closure of a complete epidermal layer with a minimum of scarring.
Integra人工皮肤是治疗全层烧伤的有效手段。在大面积烧伤中，使用这种皮肤替代物可能会成为首选治疗方法。人工皮肤由牛胶原蛋白和硫酸软骨素-6的真皮替代物以及合成聚硅氧烷聚合物（硅橡胶）的表皮层组成。在应用后的7天至2年期间，从131名患者身上获取了系列活检标本。在这项组织学研究中，识别出了六个连续的修复阶段。此外，伤口区域偶尔会出现异常的组织学特征、嗜酸性粒细胞浸润和/或巨噬细胞衍生的巨细胞形成；然而，这些发现与Integra人工皮肤的阴性反应在临床上并无关联。除了极少数例外情况，均获得了良好的修复效果。实现了完整的真皮以及完整表皮层的最终闭合，且瘢痕形成最少。
