Faculty of Physics, Warsaw University of Technology, Koszykowa 75, Warsaw, Poland.
Physiol Meas. 2010 Dec;31(12):1635-49. doi: 10.1088/0967-3334/31/12/006. Epub 2010 Nov 12.
The heart rate variability of 10 healthy males (age 26 - 4/+ 3 y) and 49 patients with hypertrophic cardiomyopathy (HCM) (25 males, 24 females, age 29.5 - 11.5/+ 10.5 y) was studied. We applied Kramers-Moyal expansion to extract the drift and diffusion terms of the Langevin equation for the RR interval time series. These terms may be used for a stochastic reconstruction of the time series and for description of the properties of heart rate variability. New parameters characterizing the diffusion term are proposed: the coefficients of the linear fit to the left (LCF) and right (RCF) branch of the dependence of the diffusion term on the rescaled heart rate. Relations of the new parameters to classical echocardiography parameters were studied. Using the relation between the difference LCF-RCF and the left ventricular systolic diameter, the HCM patients studied were divided into three groups. In addition, comparison of the properties of the heart rate variability in the HCM group with that obtained for the healthy young men showed that the parameter LCF-RCF may be treated as a measure of the effect of HCM on heart rate variability and may have diagnostic value.
我们研究了 10 名健康男性（年龄 26-4/ + 3 岁）和 49 名肥厚型心肌病（HCM）患者（25 名男性，24 名女性，年龄 29.5-11.5/ + 10.5 岁）的心率变异性。我们应用 Kramers-Moyal 展开从 RR 间隔时间序列中提取 Langevin 方程的漂移和扩散项。这些项可用于时间序列的随机重建和描述心率变异性的特性。提出了表征扩散项的新参数：扩散项对重标心率的左（LCF）和右（RCF）分支的线性拟合的系数。研究了新参数与经典超声心动图参数之间的关系。利用 LCF-RCF 差值与左心室收缩直径之间的关系，将研究的 HCM 患者分为三组。此外，将 HCM 组的心率变异性特性与健康年轻男性的心率变异性特性进行比较表明，LCF-RCF 参数可作为评估 HCM 对心率变异性影响的指标，具有诊断价值。
