Department of Geriatric Behavioral Neurology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Eur Neurol. 2010;64(6):337-44. doi: 10.1159/000322121. Epub 2010 Nov 13.
Deficits in the cholinergic system are pronounced in dementia with Lewy bodies (DLB) and are more severe in patients with visual hallucinations (VHs). The aim is to identify the occipital glucose metabolism patterns by positron emission tomography (PET) and the changes following donepezil treatment. 13 DLB patients with VHs were enrolled in the study. After the first FDG-PET study, 5 mg/day donepezil was administered orally, and a second PET study was performed 3 months later. After donepezil administration, VHs disappeared completely in 6 patients, and the PET studies revealed significantly decreased glucose metabolism in the medial occipital cortex. These results suggest that VHs in DLB were associated with impaired glucose metabolism in the medial occipital cortex. Donepezil treatment may modify regional glucose metabolism.
路易体痴呆（DLB）患者的胆碱能系统明显受损，且有视觉幻觉（VH）的患者更为严重。本研究旨在通过正电子发射断层扫描（PET）来确定枕叶葡萄糖代谢模式，并观察多奈哌齐治疗后的变化。本研究共纳入 13 例有 VH 的 DLB 患者。首次进行氟脱氧葡萄糖-PET 研究后，患者开始口服多奈哌齐 5mg/天，3 个月后进行第二次 PET 研究。多奈哌齐治疗后，6 例患者的 VH 完全消失，PET 研究显示中枕叶皮质的葡萄糖代谢明显降低。这些结果表明，DLB 中的 VH 与中枕叶皮质的葡萄糖代谢受损有关。多奈哌齐治疗可能会改变局部葡萄糖代谢。
