Egyptian IVF-ET Center, Maadi, Egypt;
Int J Womens Health. 2010 Aug 9;2:89-98. doi: 10.2147/ijwh.s9586.
To determine whether there is a difference in outcome between different ovulation-induced cycles after frozen-thawed embryo transfer (FET).
We searched the Cochrane Menstrual Disorders and Subfertility Group's trials register in May 2009, the Cochrane Central Register of Controlled Trials (Cochrane Library, Issue 1, 2008), ISI Web of Knowledge (1985 to August 2009), and reference lists of articles. Relevant conference proceedings were hand-searched and researchers in the field were contacted. Randomized controlled trials and retrospective studies were included, comparing the various cycle regimens and different methods during FET in assisted reproductive technology, ie, in vitro fertilization and intracytoplasmic sperm injection.
Using the agonist long protocol for downregulation, five trials provided extractable data for live-birth rates, ongoing pregnancy, and clinical pregnancy rates following FET. One trial provided extractable data for clinical pregnancy rate. There was no evidence of a significant difference in any outcome between the users of urinary gonadotropins versus recombinant follicle-stimulating hormone. Data on implantation and miscarriage rates following FET were not available for analysis.
It seems that clinical pregnancy rate after FET is not influenced by the type of gonadotropins used. Research should be directed towards improving freezing and thawing techniques.
确定冻融胚胎移植（FET）后不同诱发排卵周期的结局是否存在差异。
我们于 2009 年 5 月检索了 Cochrane 月经紊乱和不育症治疗组试验注册库、Cochrane 图书馆对照试验中心注册库（2008 年第 1 期）、ISI Web of Knowledge（1985 年至 2009 年 8 月）以及文章参考文献列表。手工检索了相关会议记录，并联系了该领域的研究人员。纳入了比较辅助生殖技术（即体外受精和卵胞浆内单精子注射）中 FET 时不同周期方案和不同方法的随机对照试验和回顾性研究。
使用激动剂长方案下调，5 项试验提供了活产率、持续妊娠率和 FET 后临床妊娠率的可提取数据。1 项试验提供了临床妊娠率的可提取数据。在使用尿促性腺激素与重组卵泡刺激素方面，任何结局均无显著差异的证据。FET 后种植率和流产率的数据无法进行分析。
FET 后临床妊娠率似乎不受使用的促性腺激素类型的影响。研究应致力于改善冷冻和解冻技术。
