Laboratoire de Chimie de Coordination, Centre National de la Recherche Scientifique, 205 route de Narbonne, 77 Toulouse, France.
Metallomics. 2010 Nov;2(11):741-4. doi: 10.1039/c0mt00027b. Epub 2010 Oct 21.
The reactive oxygen species H₂O₂ promotes the Zn₇-metallothionein-3 induced Aβ(40) aggregation of fibrillar type structures via slow cysteine oxidation and Zn(2+) release, whereas amorphous aggregates are formed by addition of Zn(2+) to Aβ(40).
活性氧物种 H₂O₂ 通过缓慢的半胱氨酸氧化和 Zn(2+)释放促进 Zn₇-金属硫蛋白-3 诱导的纤维状 Aβ(40)聚集，形成无定形聚集物则是通过向 Aβ(40)中添加 Zn(2+)实现的。
