Animal Physiology Unit, Department of Cellular Biology, Physiology and Immunology, Faculty of Biosciences, Institute of Neurosciences, Universitat Autonoma Barcelona, Bellaterra, 08193, Barcelona, Spain.
J Biol Inorg Chem. 2011 Oct;16(7):1103-13. doi: 10.1007/s00775-011-0802-y. Epub 2011 Jun 16.
Since the seminal discoveries of Bert Vallee regarding zinc and metallothioneins (MTs) more than 50 years ago, thousands of studies have been published concerning this fascinating story. One of the most active areas of research is the involvement of these proteins in the inflammatory response in general, and in neuroinflammation in particular. We describe the general aspects of the inflammatory response, highlighting the essential role of the major cytokine interleukin-6, and review briefly the expression and function of MTs in the central nervous system in the context of neuroinflammation. Particular attention is paid to the Tg2576 Alzheimer disease mouse model and the preliminary results obtained in mice into which human Zn(7)MT-2A was injected, which suggest a reversal of the behavioral deficits while enhancing amyloid plaque load and gliosis.
自 50 多年前 Bert Vallee 关于锌和金属硫蛋白 (MTs) 的开创性发现以来，已经发表了数千篇关于这个引人入胜的故事的研究论文。其中最活跃的研究领域之一是这些蛋白质在一般炎症反应中的作用，特别是在神经炎症中的作用。我们描述了炎症反应的一般方面，强调了主要细胞因子白细胞介素-6 的重要作用，并简要回顾了 MTs 在中枢神经系统中的表达和功能在神经炎症中的作用。特别关注 Tg2576 阿尔茨海默病小鼠模型和向其中注射人 Zn(7)MT-2A 的小鼠的初步结果，这些结果表明行为缺陷得到了逆转，同时增强了淀粉样斑块负荷和神经胶质增生。
