Magnetic Resonance Center (CERM)-University of Florence, Via L. Sacconi 6, Sesto Fiorentino, Italy.
Metallomics. 2010 Jan;2(1):39-51. doi: 10.1039/b912156k. Epub 2009 Sep 29.
Bioinformatics is a central discipline in modern life sciences aimed at describing the complex properties of living organisms starting from large-scale data sets of cellular constituents such as genes and proteins. In order for this wealth of information to provide useful biological knowledge, databases and software tools for data collection, analysis and interpretation need to be developed. In this paper, we review recent advances in the design and implementation of bioinformatics resources devoted to the study of metals in biological systems, a research field traditionally at the heart of bioinorganic chemistry. We show how metalloproteomes can be extracted from genome sequences, how structural properties can be related to function, how databases can be implemented, and how hints on interactions can be obtained from bioinformatics.
生物信息学是现代生命科学的一个核心学科，旨在从基因和蛋白质等细胞成分的大规模数据集出发，描述生物体的复杂特性。为了使这些丰富的信息提供有用的生物学知识，需要开发用于数据收集、分析和解释的数据库和软件工具。在本文中，我们回顾了近年来在设计和实现生物信息学资源方面的进展，这些资源专门用于研究生物系统中的金属，这是生物无机化学的一个传统核心研究领域。我们展示了如何从基因组序列中提取金属蛋白质组，如何将结构性质与功能联系起来，如何实现数据库，以及如何从生物信息学中获得关于相互作用的提示。
