铁催化的 4-炔基酮与伯胺的[4C+1N]环化反应合成多取代吡咯。

Iron-catalyzed synthesis of polysubstituted pyrroles via [4C+1N] cyclization of 4-acetylenic ketones with primary amines.

机构信息

Department of Chemistry, Northeast Normal University, 5268 Renmin Street, 130024 Changchun, China.

出版信息

Chem Commun (Camb). 2011 Jan 14;47(2):809-11. doi: 10.1039/c0cc03802d. Epub 2010 Nov 11.

Abstract

A highly efficient iron-catalyzed approach to polysubstituted pyrroles has been developed through the [4C+1N] cyclization of 4-acetylenic ketones with primary amines, leading to the synthesis of a variety of tetra- and fully-substituted pyrroles as well as fused pyrrole derivatives in good to excellent yields.

摘要

发展了一种高效的铁催化方法，通过 4-炔基酮与伯胺的[4C+1N]环化反应，合成了各种四取代和全取代的吡咯以及稠合的吡咯衍生物，产率良好至优秀。